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Systemic Cholesterol Embolization Syndrome Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibody
Author: T. Sugimoto, Y. Morita, Y. Yokomaku, K. Isshiki, K. Kanasaki, Y. Eguchi, D. Koya and A. Kashiwagi 1
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| A 75-year-old man was transferred to our department because of development of severe renal impairment. |
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Diffuse Alveolar Hemorrhage and Pulmonary Capillaritis Due to Propylthiouracil
Author: S. S. Dhillon, D. Singh, N. Doe, A. M. Qadri, S.Ricciardi, M. Schwarz
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| Describes the devastating consequences of spontaneous coronary dissection in a 36-year-old female patient. |
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Myeloperoxidase and Plasminogen Activator Inhibitor 1 Play a Central Role in Ventricular Remodeling after Myocardial Infarction
Author: A. Askari, M.L. Brennan, X. Zhou, J. Drinko, A. Morehead, J.D. Thomas, E.J. Topol, S.L. Hazen, M. Penn
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| These data offer a mechanistic link between inflammation and LV remodeling by demonstrating a heretofore unrecognized role for MPO and PAI-1 in orchestrating the myocardial response to AMI. |
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Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
Author: L. Zheng, B. Nukuna, M. Brennan, M. Sun, M. Goormastic, M. Settle, D. Schmitt, X. Fu, L. Thomson, P.L. Fox, H. Ischiropoulos, J.D. Smith, M. Kinter, and S.L. Hazen
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| Study shows that apoA-I is selective target for MPO-catalyzed nitration and chlorination in vivo and that MPO-catalyzed oxidation of HDL and apoA-I results in selective inhibition in ABCA1-dependent cholesterol efflux from macrophages. |
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